Metabolic acidosis as adverse effect of Beta agonist
-Beta angonist cause increased in cAMP.
-cAMP promote glycogenolysis , lipolysis and glycolysis.
-glycogenolysis produce glucose-6-phosphate.
-usually glycogenolysis occurs in liver and skeletal muscle.
-glucose-6-phosphate produce in the liver will be converted to glucose by glucose-6-phosphatase and then release to the blood to be use.
-But in skeletal muscle, there is lack of this enzyme (glucose-6-phosphatase).
-hence glucose-6-phosphate that produced in the skeletal will be convert to pyruvate to enter Krebs cycles for energy production.
-however, the high concentration of fatty acid (increase lipolysis stimulate by cAMP) inhibit oxidation of pyruvate to Acetyl CoA to enter the Krebs cycle.
-the abundance of pyruvates converted to lactate.
Apart from Beta agonist, glucocorticoids and theophylline also increase the cAMP production.