Anaphylaxis: Should we give IM Adrenaline in normotensive patient?

As a result current guidelines suggest adrenaline should be given as soon as possible.

Adrenaline has physiological benefits in the treatment of anaphylaxis:

1. stimulation of α adrenoceptors increases peripheral vascular resistance thus improving blood pressure and coronary perfusion, reversing peripheral vasodilation, and decreasing angioedema.

2. Stimulation of β1 adrenoceptors has both positive inotropic and chronotropic cardiac effects.

3. Stimulation of β2 receptors causes bronchodilation as well as increasing intracellular cyclic adenosine monophosphate production in mast cells and basophils, reducing release of inflammatory mediators.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s